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This bypasses both gut degradation and first-pass hepatic metabolism, which is why the sublingual route has long been used in medicine for compounds where rapid, high-absorption delivery matters
Because vitamin (especially folate) supplementation can efficiently reduce plasma homocysteine levels, further prospective cohort studies and ongoing, randomized, placebo-controlled trials will determine the efficiency of folate supplementation, possibly in combination with vitamins B 12 and B 6 , in the prevention and correction of vascular disorders related to moderate hyperhomocysteinemia
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Materials and methods: Continuous glucose monitoring (CGM) data from 185 study participants with type 1 diabetes using MDI were collected under everyday conditions for up to 13 weeks (mean age: 41.8 years, mean HbA1c: 7.6%, 8905 patient-days)
Fray et al., 2000)
